Aptamer-conjugated nanomaterials for bioanalysis and biotechnology applications

被引：105

作者：

Chen, Tao ^{[1
,2
,3
]}

Shukoor, Mohammed Ibrahim ^{[1
,2
,3
]}

Chen, Yan ^{[1
,2
,3
,4
]}

Yuan, Quan ^{[1
,2
,3
]}

Zhu, Zhi ^{[1
,2
,3
]}

Zhao, Zilong ^{[1
,2
,3
]}

Gulbakan, Basri ^{[1
,2
,3
]}

Tan, Weihong ^{[1
,2
,3
,4
]}

机构：

[1] Univ Florida, Dept Chem, Shands Canc Ctr, Ctr Res Bio Nano Interface,Univ Florida Genet Ins, Gainesville, FL 32611 USA

[2] Univ Florida, Dept Physiol & Funct Genom, Shands Canc Ctr, Ctr Res Bio Nano Interface,Univ Florida Genet Ins, Gainesville, FL 32611 USA

[3] Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA

[4] Hunan Univ, Coll Chem & Chem Engn, Coll Biol, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

NANOSCALE | 2011年 / 3卷 / 02期

关键词：

SURFACE-PLASMON RESONANCE; ENHANCED RAMAN-SCATTERING; BLOCK-COPOLYMER MICELLES; GOLD NANOPARTICLES; CARBON NANOTUBES; DRUG-DELIVERY; SILICA NANOPARTICLES; DNA APTAMER; CELLULAR UPTAKE; LIVE CELLS;

D O I：

10.1039/c0nr00646g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In recent years, nanomaterials have captured the attention of scientists from a wide spectrum of domains. With their unique properties, nanomaterials offer great promise for numerous applications, ranging from catalysis to energy harvesting and information technology. Functionalized with the desired biomolecules, nanomaterials can also be utilized for many biomedical applications. This paper summarizes recent achievements in the use of aptamer-conjugated nanomaterials for bioanalysis and biotechnology applications. First, we discuss the features and properties of aptamers and then illustrate the use of aptamer-conjugated nanomaterials as sensing platforms and delivery vehicles, emphasizing how such integration can result in enhanced sensitivity and selectivity.

引用

页码：546 / 556

页数：11

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