DNA block copolymer micelles - A combinatorial tool for cancer Nanotechnology

被引：164

作者：

Alemdaroglu, Fikri E. ^{[1
]}

Alemdaroglu, N. Ceren ^{[2
]}

Langguth, Peter ^{[2
]}

Herrmann, Andreas ^{[1
]}

机构：

[1] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Inst Pharm, D-55099 Mainz, Germany

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 05期

关键词：

D O I：

10.1002/adma.200700866

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel micelle platform consisting of amphiphilic DNA block copolymers is introduced for chemotherapeutic drug delivery, allowing combinatorial testing of the drug carrier system. Oligodeoxy-nucleotide modified targeting units are "clicked" into the micelle corona by hybridization, allowing perfect control of surface functionalities of the nano-particle system. Cancer cells are efficiently killed when targeting units and chemotherapeutic act together within the DNA block copolymer aggregates.

引用

页码：899 / +

页数：5

共 42 条

[1] DNA meets synthetic polymers - highly versatile hybrid materials [J].

Alemdaroglu, Fikri E. ;

Herrmann, Andreas .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (09) :1311-1320

[2] DNA multiblock copolymers [J].

Alemdaroglu, Fikri E. ;

Safak, Meryem ;

Wang, Jie ;

Berger, Ruediger ;

Herrmann, Andreas .

CHEMICAL COMMUNICATIONS, 2007, (13) :1358-1359

[3] DNA-templated synthesis in three dimensions: Introducing a micellar scaffold for organic reactions [J].

Alemdaroglu, Fikri E. ;

Ding, Ke ;

Berger, Ruediger ;

Herrmann, Andreas .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (25) :4206-4210

[4] Biofunctionalized pH-responsive microgels for cancer cell targeting: Rational design [J].

Das, M ;

Mardyani, S ;

Chan, WCW ;

Kumacheva, E .

ADVANCED MATERIALS, 2006, 18 (01) :80-83

[5] Engineering the structural properties of DNA block copolymer micelles by molecular recogntition [J].

Ding, Ke ;

Alemdaroglu, Fikri E. ;

Boersch, Michael ;

Berger, Ruediger ;

Herrmann, Andreas .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (07) :1172-1175

[6] Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy [J].

Elnakat, H ;

Ratnam, M .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (08) :1067-1084

[7]

ELWOOD PC, 1989, J BIOL CHEM, V264, P14893

[8]

EUN SL, 2003, J CONTROL RELEASE, P103

[9] Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment [J].

Hobbs, SK ;

Monsky, WL ;

Yuan, F ;

Roberts, WG ;

Griffith, L ;

Torchilin, VP ;

Jain, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) :4607-4612

[10] Nano-imaging of polymers by optical microscopy [J].

Ito, S ;

Aoki, H .

POLYMER ANALYSIS, POLYMER THEORY, 2005, 182 :131-169

← 1 2 3 4 5 →