Significance thresholds for quantitative trait locus mapping under selective genotyping

被引：26

作者：

Manichaikul, Ani

Palmer, Abraham A.

Sen, Saunak

Broman, Karl W.

机构：

[1] Johns Hopkins Univ, Dept Biostat, Baltimore, MD 21205 USA

[2] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA

[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94107 USA

来源：

GENETICS | 2007年 / 177卷 / 03期

关键词：

D O I：

10.1534/genetics.107.080093

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In the case of selective genotyping, the usual permutation test to establish statistical significance for quantitative trait locus (QTL) mapping can give inappropriate significance thresholds, especially when the phenotype distribution is skewed. A stratified permutation test should be used, with phenotypes shuffled separately within the genotyped and ungenotyped individuals.

引用

页码：1963 / 1966

页数：4

共 11 条

[1]

Broman KW, 2003, GENETICS, V163, P1169

[2] R/qtl: QTL mapping in experimental crosses [J].