pH-induced change in the rate-determining step for the hydrolysis of the Asp/Asn-derived cyclic-imide intermediate in protein degradation

被引:32
作者
Xie, ML
VanderVelde, D
Morton, M
Borchardt, RT
Schowen, RL
机构
[1] UNIV KANSAS,DEPT PHARMACEUT CHEM,LAWRENCE,KS 66046
[2] UNIV KANSAS,NMR LAB,LAWRENCE,KS 66046
关键词
D O I
10.1021/ja9606182
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:8955 / 8956
页数:2
相关论文
共 15 条
[11]   ANTIBODY-CATALYZED REARRANGEMENT OF A PEPTIDE-BOND - MECHANISTIC AND KINETIC INVESTIGATIONS [J].
LIOTTA, LJ ;
GIBBS, RA ;
TAYLOR, SD ;
BENKOVIC, PA ;
BENKOVIC, SJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (17) :4729-4741
[12]   A CATALYTIC ANTIBODY FOR IMIDE HYDROLYSIS FEATURING A BIFUNCTIONAL TRANSITION-STATE MIMIC [J].
LIOTTA, LJ ;
BENKOVIC, PA ;
MILLER, GP ;
BENKOVIC, SJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (01) :350-351
[13]   CAPILLARY ZONE ELECTROPHORESIS OF PEPTIDE-FRAGMENTS FROM TRYPSIN DIGESTION OF BIOSYNTHETIC HUMAN GROWTH-HORMONE [J].
NIELSEN, RG ;
RIGGIN, RM ;
RICKARD, EC .
JOURNAL OF CHROMATOGRAPHY, 1989, 480 :393-401
[14]  
ROHER AE, 1993, J BIOL CHEM, V268, P3072
[15]   USE OF HIGH-PERFORMANCE CAPILLARY ELECTROPHORESIS TO MONITOR CHARGE HETEROGENEITY IN RECOMBINANT-DNA DERIVED PROTEINS [J].
WU, SL ;
TESHIMA, G ;
CACIA, J ;
HANCOCK, WS .
JOURNAL OF CHROMATOGRAPHY, 1990, 516 (01) :115-122