A Novel Aux/IAA28 Signaling Cascade Activates GATA23-Dependent Specification of Lateral Root Founder Cell Identity

被引：387

作者：

De Rybel, Bert ^{[1
,2
,3
]}

Vassileva, Valya ^{[1
,2
,4
]}

Parizot, Boris ^{[1
,2
]}

Demeulenaere, Marlies ^{[1
,2
]}

Grunewald, Wim ^{[1
,2
]}

Audenaert, Dominique ^{[1
,2
]}

Van Campenhout, Jelle ^{[1
,2
]}

Overvoorde, Paul ^{[5
]}

Jansen, Leentje ^{[1
,2
]}

Vanneste, Steffen ^{[1
,2
]}

Moeller, Barbara ^{[3
]}

Wilson, Michael ^{[6
,7
]}

Holman, Tara ^{[6
,7
]}

Van Isterdael, Gert ^{[1
,2
]}

Brunoud, Geraldine ^{[8
,9
]}

Vuylsteke, Marnik ^{[1
,2
]}

Vernoux, Teva ^{[8
,9
]}

De Veylder, Lieven ^{[1
,2
]}

Inze, Dirk ^{[1
,2
]}

Weijers, Dolf ^{[3
]}

Bennett, Malcolm J. ^{[6
,7
]}

Beeckman, Tom ^{[1
,2
]}

机构：

[1] VIB, Dept Plant Syst Biol, B-9052 Ghent, Belgium

[2] Univ Ghent, Dept Plant Biotechnol & Genet, B-9052 Ghent, Belgium

[3] Wageningen Univ, Lab Biochem, NL-6703 HA Wageningen, Netherlands

[4] Bulgarian Acad Sci, Inst Plant Physiol & Genet, BU-1113 Sofia, Bulgaria

[5] Macalester Coll, Dept Biol, St Paul, MN 55105 USA

[6] Univ Nottingham, Plant Sci Div, Loughborough LE12 5RD, Leics, England

[7] Univ Nottingham, Ctr Plant Integrat Biol, Sch Biosci, Loughborough LE12 5RD, Leics, England

[8] CNRS, Lab Reprod & Dev Plantes, F-69364 Lyon 07, France

[9] Univ Lyon, Ecole Normale Super Lyon, F-69364 Lyon 07, France

来源：

CURRENT BIOLOGY | 2010年 / 20卷 / 19期

基金：

英国生物技术与生命科学研究理事会;

关键词：

OF-FUNCTION MUTATION; ARABIDOPSIS-THALIANA; AUXIN TRANSPORT; INITIATION; GENE; FATE; DIFFERENTIATION; EXPRESSION; PERICYCLE; DIVISIONS;

D O I：

10.1016/j.cub.2010.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Lateral roots are formed at regular intervals along the main root by recurrent specification of founder cells. To date, the mechanism by which branching of the root system is controlled and founder cells become specified remains unknown. Results: Our study reports the identification of the auxin regulatory components and their target gene, GATA23, which control lateral root founder cell specification. Initially, a meta-analysis of lateral root-related transcriptomic data identified the GATA23 transcription factor. GATA23 is expressed specifically in xylem pole pericycle cells before the first asymmetric division and is correlated with oscillating auxin signaling maxima in the basal meristem. Also, functional studies revealed that GATA23 controls lateral root founder cell identity. Finally, we show that an Aux/IAA28-dependent auxin signaling mechanism in the basal meristem controls GATA23 expression. Conclusions: We have identified the first molecular components that control lateral root founder cell identity in the Arabidopsis root. These include an IAA28-dependent auxin signaling module in the basal meristem region that regulates GATA23 expression and thereby lateral root founder cell specification and root branching patterns.

引用

页码：1697 / 1706

页数：10

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