The LKB1/AMPK polarity pathway

被引：47

作者：

Mirouse, Vincent ^{[1
]}

Billaud, Marc ^{[2
]}

机构：

[1] Clermont Univ, Fac Med, GReD Lab, CNRS UMR 6247,INSERM U931, F-63000 Clermont Ferrand, France

[2] Inst Albert Bonniot, CRI INSERM, UJF U823, F-38706 La Tronche, France

来源：

FEBS LETTERS | 2011年 / 585卷 / 07期

关键词：

Polarity; Metabolism; Cancer; LKB1; AMPK; Myosin II; ACTIVATED PROTEIN-KINASE; EPITHELIAL-CELLS; ENERGETIC STRESS; LKB1; DYSTROGLYCAN; AMPK; POLARIZATION; EXPRESSION; BREAST; GROWTH;

D O I：

10.1016/j.febslet.2010.12.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The LKB1 tumor suppressor kinase is an activator of the AMP-activated protein kinase (AMPK), a metabolic gauge that responds to variations of cellular energetic levels by favoring catabolic versus anabolic processes. Recent studies have provided substantial evidence that LKB1 and AMPK control cell polarity from invertebrates to mammals. This review examines how the LKB1-AMPK pathway, in conjunction with other positional signals, converts energy-sensing information into the activation of Myosin II to maintain epithelial-cell architecture but also to complete cell division. This molecular link between polarity and metabolism may constitute an ancient stress-response protective mechanism that was co-opted for tumor suppression during evolution. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：981 / 985

页数：5

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