Suzuki-Miyaura cross-coupling with quasi-heterogeneous palladium

被引:140
作者
Conlon, DA
Pipik, B
Ferdinand, S
LeBlond, CR
Sowa, JR
Izzo, B
Collins, P
Ho, GJ
Williams, JM
Shi, YJ
Sun, YK
机构
[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA
[2] Merck Res Labs, Dept Chem Engn Res & Dev, Rahway, NJ 07065 USA
[3] Seton Hall Univ, Dept Biochem & Chem, S Orange, NJ 07079 USA
关键词
cross-coupling; heterogeneous catalyst; palladium; palladium leaching; Suzuki-Miyaura;
D O I
10.1002/adsc.200303036
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The Suzuki-Miyaura cross-coupling reaction using heterogeneous Pd/C has a homogeneous component. The soluble palladium concentration increases during the reaction reaching a maximum at ca. 90% conversion before falling to < 4 ppm.
引用
收藏
页码:931 / 935
页数:5
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