An extremely stable and orthogonal DNA base pair with a simplified three-carbon backbone

被引：118

作者：

Zhang, LL ^{[1
]}

Meggers, E ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 01期

关键词：

D O I：

10.1021/ja043904j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A nucleotide C3HQ with a minimal three-carbon backbone displays unprecedented pairing strength and orthogonality in a homopair C3HQ:C3HQ in the presence of one equivalent of Cu2+. The pairing stability in DNA even exceeds the related base pair having the regular 2′-deoxyribose backbone. This discovery of a synergy between an artificial backbone and base-pairing scheme opens new avenues for the economical design of modified oligonucleotides with tailored properties. Copyright © 2005 American Chemical Society.

引用

页码：74 / 75

页数：2

共 16 条

[1] Structure of a copper-mediated base pair in DNA [J].