Growth differentiation factor 15 in cardiovascular diseases: from bench to bedside

被引：117

作者：

Xu, Xinye ^{[1
]}

Li, Zijian

Gao, Wei

机构：

[1] Peking Univ, Dept Cardiol, Hosp 3, Beijing 100091, Peoples R China

来源：

BIOMARKERS | 2011年 / 16卷 / 06期

基金：

美国国家科学基金会;

关键词：

GDF-15; cardiovascular disease; myocardial protection; MACROPHAGE-INHIBITORY CYTOKINE-1; DRUG-ACTIVATED GENE-1; BETA SUPERFAMILY MEMBER; RISK STRATIFICATION; INDUCED APOPTOSIS; CANCER-CELLS; HEART-FAILURE; NAG-1; EXPRESSION; UP-REGULATION; HUMAN BREAST;

D O I：

10.3109/1354750X.2011.580006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Context: Growth differentiation factor 15 (GDF-15) is a novel cytokine showing close association with cardiovascular diseases. The biological mechanism and clinical use of GDF-15 in cardiovascular diseases have been well demonstrated. We review recent investigations from both basic research and clinical trials into the biological role of GDF-15. Methods: The data were obtained mainly from MedLine via PubMed and from our own investigations. Results: Laboratory investigations revealed that GDF-15 has biphasic effects on cellular survival by several signaling pathways. GDF-15 participates in several cardiovascular pathological processes such as cardiac remodeling, ischemia/reperfusion injury and atherosclerotic plaque formation. As well, GDF-15 was found a prognostic biomarker of heart failure and acute coronary syndrome. The evidence for diagnostic or therapeutic utility is poor. Conclusion: GDF-15 has great potential as a biomarker in cardiovascular diseases, especially for prognosis, and is seen as a myocardial protective cytokine, but the exact mechanism of GDF-15 in cardiovascular diseases remains unknown.

引用

收藏

页码：466 / 475

页数：10

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