Mercury-free preparation and selective reactions of propargyl (and propargylic) grignard Reagents

被引：42

作者：

Acharya, Hukum P. ^{[1
]}

Miyoshi, Kei ^{[1
]}

Kobayashi, Yuichi ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 18期

关键词：

D O I：

10.1021/ol071397f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

ZnBr2 was found to catalyze formation of propargyl and propargylic Grignard reagents, and thus put an end to the standard method using a mercury catalyst. The Grignard reagents were submitted to addition reaction with carbonyl compounds and allylation with the cyclic monoacetate to afford the propargyl-type products selectively. Furthermore, the product from the monoacetate was transformed to an acetylene analogue of 2-(5,6-epoxyisoprostane A(2))phosphorylcholines.

引用

页码：3535 / 3538

页数：4

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