Phenothiazinium-based photosensitizers: antibacterials of the future?

被引：35

作者：

Phoenix, DA ^{[1
]}

Harris, F

机构：

[1] Univ Cent Lancashire, Fac Sci, Deans Off, Preston PR1 2HE, Lancs, England

[2] Univ Cent Lancashire, Dept Forens & Invest Sci, Preston PR1 2HE, Lancs, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2003年 / 9卷 / 07期

关键词：

D O I：

10.1016/S1471-4914(03)00115-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenothiazinium-based molecules exhibit phototoxicity against a broad range of bacteria. In general, these photosensitizers use several cellular uptake pathways, coupled to type II mechanisms of photo-oxidation, to inflict bacterial damage. These molecules show potential to act as novel alternatives to conventional antibiotics.

引用

页码：283 / 285

页数：3