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Hydrophobic nanopillars initiate mesenchymal stem cell aggregation and osteo-differentiation

被引：103
作者：
Brammer, Karla S. [1 ]
Choi, Chulmin [1 ]
Frandsen, Christine J. [1 ]
Oh, Seunghan [2 ]
Jin, Sungho [1 ]
机构：
[1] Univ Calif San Diego, La Jolla, CA 92093 USA
[2] Wonkwang Univ, Coll Dent, Dept Dent Biomat, Iksan, South Korea
来源：
ACTA BIOMATERIALIA | 2011年 / 7卷 / 02期
关键词：
Hydrophobic; Gold; Nanopillar; Mesenchymal stem cell; Osteo-differentiation; SILICON NANOWIRE ARRAYS; IN-VITRO; PROTEIN ADSORPTION; NANOSTRUCTURED SURFACES; TIO2; NANOTUBES; ADHESION; NANOTOPOGRAPHY; TOPOGRAPHY; CULTURE; ORIENTATION;
D O I：
10.1016/j.actbio.2010.09.022
中图分类号：
R318 [生物医学工程];
学科分类号：
100103 [病原生物学];
摘要：
Surface engineering approaches that alter the physical topography of a substrate could be used as an effective tool and as an alternative to biochemical means of directing stem cell interactions and their subsequent differentiation. In this paper we compare hydrophobic micro- vs. nanopillar type fabrication techniques for probing mesenchymal stem cell (MSC) interaction with the surface physical environment. The roles played by the topography of the nanopillar in particular influenced MSC growth and allowed for regulatory control of the stem cell fate. The nanopillar induced large 3-D cell aggregates to form on the surface which had up-regulated osteogenic specific matrix components. The ability to control MSC differentiation, using only the topographical factors, has a profound effect on both MSC biology and tissue engineering. This study aims to highlight the importance of the physical material carrier in stem cell based tissue engineering schemes. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：683 / 690
页数：8
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