Cell signaling arising from nanotopography: implications for nanomedical devices

被引:74
作者
Curtis, Adam S. G. [1 ]
Dalby, Matthew [1 ]
Gadegaard, Nikolaj [1 ]
机构
[1] Univ Glasgow, Ctr Cell Engn, Div Infect & Immun, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
基金
英国生物技术与生命科学研究理事会;
关键词
mechanical forces-mechanotransduction; nanochemical signals; nanodevices; nanoscale signaling; topographic signals;
D O I
10.2217/17435889.1.1.67
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
This review discusses the roles in signaling to cells by nanochemical, nanostructural (nanotopography) and mechanical means, as well as recent work and trends in nanobioscience that are relevant to therapeutic applications. It is suggested that the mechanical results may often integrate the other two types of signal. Although the field is still in an almost embryonic but rapidly developing state, it is possible to envisage potential medical devices. Nanoparticle-based therapies are recognized as having some appreciable hazards, while those based on extended nanofeatured surfaces probably have fewer risks.
引用
收藏
页码:67 / 72
页数:6
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