Alkyne-azide click chemistry mediated carbanucleosides synthesis

被引：20

作者：

Broggi, Julie ^{[1
]}

Joubert, Nicolas ^{[1
]}

Aucagne, Vincent ^{[1
]}

Berteina-Raboin, Sabine ^{[1
]}

Diez-Gonzalez, S. ^{[2
]}

Nolan, Steve ^{[2
]}

Topalis, Dimitri ^{[3
]}

Deville-Bonne, Dominique ^{[3
]}

Balzarini, Jan ^{[4
]}

Neyts, Johan ^{[4
]}

Andrei, Graciela ^{[4
]}

Snoeck, Robert ^{[4
]}

Agrofoglio, Luigi A. ^{[1
]}

机构：

[1] Univ Orleans, Inst Chim Organ & Analyt, UMR 6005, Orleans, France

[2] Inst Chem Res Catalonia ICIQ, Tarragona, Spain

[3] Univ Paris 06, Lab Enzymol & Mol Fonct, FRE CNRS 2852, Paris, France

[4] Katholieke Univ Leuven, Rega Inst Med Res, Dept Microbiol & Immunol, B-3000 Louvain, Belgium

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2007年 / 26卷 / 10-12期

关键词：

click chemistry; Huisgen cycloaddition; carbanucleosides; alkyne-azide;

D O I：

10.1080/15257770701534139

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Hitherto unknown 1,4-disubstituted-[1,2,3]-triazolo-4',4'-dihydroxymethyl-3'-deoxycarbanucleosides were synthesized based on a "click approach." Various alkynes were introduced on a key azido intermediate by the "click" 1,3-dipolar Huisgen cycloaddition. Their antiviral activities and cellular toxicities were evaluated on vaccinia virus. None of the synthesized compounds exhibited a significant antiviral activity.

引用

页码：1391 / 1394

页数：4

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