An integrated model of the recognition of Candida albicans by the innate immune system

被引：695

作者：

Netea, Mihai G. ^{[1
,2
]}

Brown, Gordon D. ^{[3
]}

Kullberg, Bart Jan ^{[1
,2
]}

Gow, Neil A. R. ^{[4
]}

机构：

[1] Univ Nijmegen St Radboud Hosp, Med Ctr, Dept Med, Nijmegen, Netherlands

[2] Univ Nijmegen St Radboud Hosp, Med Ctr, Ctr Infect Dis, Nijmegen, Netherlands

[3] Univ Cape Town, Inst Infect Dis & Mol Med, Div Immunol, CLS, ZA-7925 Cape Town, South Africa

[4] Univ Aberdeen, Sch Med Sci, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

NATURE REVIEWS MICROBIOLOGY | 2008年 / 6卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrmicro1815

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The innate immune response was once considered to be a limited set of responses that aimed to contain an infection by primitive 'ingest and kill' mechanisms, giving the host time to mount a specific humoral and cellular immune response. In the mid-1990s, however, the discovery of Toll-like receptors heralded a revolution in our understanding of how microorganisms are recognized by the innate immune system, and how this system is activated. Several major classes of pathogen-recognition receptors have now been described, each with specific abilities to recognize conserved bacterial structures. The challenge ahead is to understand the level of complexity that underlies the response that is triggered by pathogen recognition. In this Review, we use the fungal pathogen Candida albicans as a model for the complex interaction that exists between the host pattern-recognition systems and invading microbial pathogens.

引用

页码：67 / 78

页数：12

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