Nutritional regulation of the growth hormone and insulin-like growth factor-binding proteins

被引：81

作者：

Ketelslegers, JM ^{[1
]}

Maiter, D ^{[1
]}

Maes, M ^{[1
]}

Underwood, LE ^{[1
]}

Thissen, JP ^{[1
]}

机构：

[1] UNIV N CAROLINA, SCH MED, DEPT PEDIAT, CHAPEL HILL, NC 27515 USA

来源：

HORMONE RESEARCH | 1996年 / 45卷 / 3-5期

关键词：

nutrition; growth hormone; insulin-like growth factor; IGF-binding protein;

D O I：

10.1159/000184797

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Both growth hormone (GH) and insulin-like growth factors (IGFs) associate with specific binding proteins. Besides control by hormones, these binding proteins are nutritionally regulated. The GH-binding protein (GHBP) is the extracellular portion of the GH receptor. Its concentrations in circulation are decreased in severe malnutrition, reflecting a decrease in tissue GH receptor abundance. IGFs are bound to 6 different binding proteins (IGFBPs). IGFBP-3 is relatively stable and is only depressed after prolonged periods of severe malnutrition. In contrast, IGFBP-1 is regulated acutely by nutrient intake, showing major elevations after overnight fasting and rapid postprandial decreases. IGFBP-2 is highly dependent on dietary protein intake. Nutritional factors may regulate the tissue availability and the biological actions of IGFs by their actions on IGFBPs.

引用

页码：252 / 257

页数：6

共 48 条

[31] INSULIN RAPIDLY DECREASES INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 GENE-TRANSCRIPTION IN STREPTOZOTOCIN-DIABETIC RATS [J].

OOI, GT ;

TSENG, LYH ;

TRAN, MQ ;

RECHLER, MM .

MOLECULAR ENDOCRINOLOGY, 1992, 6 (12) :2219-2228

[32] REGULATION OF INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND IGF-BINDING PROTEIN-1 GENE-TRANSCRIPTION BY HORMONES AND PROVISION OF AMINO-ACIDS IN RAT HEPATOCYTES [J].

PAO, CI ;

FARMER, PK ;

BEGOVIC, S ;

VILLAFUERTE, BC ;

WU, GJ ;

ROBERTSON, DG ;

PHILLIPS, LS .

MOLECULAR ENDOCRINOLOGY, 1993, 7 (12) :1561-1568

[33] NUTRITION AND SOMATOMEDIN .1. EFFECT OF FASTING AND REFEEDING ON SERUM SOMATOMEDIN ACTIVITY AND CARTILAGE GROWTH ACTIVITY IN RATS [J].

PHILLIPS, LS ;

YOUNG, HS .

ENDOCRINOLOGY, 1976, 99 (01) :304-314

[34]

POSTELVINAY MC, 1993, J PEDIATR ENDOCRINOL, V6, P241

[35] THE EFFECT OF DIETARY-PROTEIN SUPPLEMENTATION ON INSULIN-LIKE GROWTH-FACTORS (IGFS) AND IGF-BINDING PROTEINS IN CHILDREN WITH SHIGELLOSIS [J].

PUCILOWSKA, JB ;

DAVENPORT, ML ;

KABIR, I ;

CLEMMONS, DR ;

THISSEN, JP ;

BUTLER, T ;

UNDERWOOD, LE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (06) :1516-1521

[36]

SMITH IF, 1981, P SOC EXP BIOL MED, V167, P607

[37] EFFECTS OF CALORIC OR PROTEIN RESTRICTION ON INSULIN-LIKE GROWTH-FACTOR-I (IGF-I) AND IGF-BINDING PROTEINS IN CHILDREN AND ADULTS [J].

SMITH, WJ ;

UNDERWOOD, LE ;

CLEMMONS, DR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (02) :443-449

[38] SERUM INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II CONCENTRATIONS AND GROWTH-HORMONE AND INSULIN RESPONSES TO ARGININE INFUSION IN CHILDREN WITH PROTEIN-ENERGY MALNUTRITION BEFORE AND AFTER NUTRITIONAL REHABILITATION [J].

SOLIMAN, AT ;

HASSAN, AEI ;

AREF, MK ;

HINTZ, RL ;

ROSENFELD, RG ;

ROGOL, AD .

PEDIATRIC RESEARCH, 1986, 20 (11) :1122-1130

[39] EXPRESSION OF THE GENES FOR INSULIN-LIKE GROWTH FACTOR-I (IGF-I), IGF-II, AND IGF-BINDING PROTEINS-1 AND PROTEINS-2 IN FETAL-RAT UNDER CONDITIONS OF INTRAUTERINE GROWTH-RETARDATION CAUSED BY MATERNAL FASTING [J].

STRAUS, DS ;

OOI, GT ;

ORLOWSKI, CC ;

RECHLER, MM .

ENDOCRINOLOGY, 1991, 128 (01) :518-525

[40] EFFECT OF DIETARY-PROTEIN DEPRIVATION ON INSULIN-LIKE GROWTH-FACTOR (IGF)-I AND (IGF)-II, IGF BINDING PROTEIN-2, AND SERUM-ALBUMIN GENE-EXPRESSION IN RAT [J].

STRAUS, DS ;

TAKEMOTO, CD .

ENDOCRINOLOGY, 1990, 127 (04) :1849-1860

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