CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC

被引：13

作者：

Bi, Ling ^{[1
]}

Xie, Chanlu ^{[2
,3
,4
]}

Jiao, Lijing ^{[1
]}

Jin, Shenyi ^{[1
]}

Hnit, Su Su Thae ^{[2
,3
,4
]}

Mu, Yao ^{[3
,4
]}

Wang, Yilun ^{[3
,4
]}

Wang, Qian ^{[5
,6
]}

Ge, Guangbo ^{[7
]}

Wang, Yaqiao ^{[7
]}

Zhao, Xiaodong ^{[8
]}

Shi, Xinglong ^{[8
]}

Kang, Yani ^{[9
]}

De Souza, Paul ^{[10
]}

Liu, Tao ^{[11
,12
]}

Zhou, Jia ^{[13
]}

Xu, Ling ^{[1
]}

Dong, Qihan ^{[2
,3
,4
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Dept Oncol, Shanghai, Peoples R China

[2] Univ Western Sydney, Natl Inst Complementary Med, Sch Sci & Hlth, Penrith, NSW, Australia

[3] Univ Sydney, Cent Clin Sch & Charles Perkins Ctr, Greg Brown Lab, Chinese Med Anticanc Evaluat Program, Sydney, NSW, Australia

[4] Royal Prince Alfred Hosp, Dept Endocrinol, Sydney, NSW, Australia

[5] Centenary Inst, Origins Canc Program, Camperdown, NSW, Australia

[6] Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia

[7] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai, Peoples R China

[8] Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biol, Shanghai, Peoples R China

[9] Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai, Peoples R China

[10] Univ Western Sydney, Sch Med, Campbelltown, NSW, Australia

[11] Childrens Canc Inst Australia Med Res, Sydney, NSW, Australia

[12] UNSW Med, Ctr Childhood Canc Res, Sydney, NSW, Australia

[13] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Dept Thorac Surg, Shanghai, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 03期

基金：

中国国家自然科学基金;

关键词：

c-MYC; G(0) cell cycle re-entry; lung cancer; structure-specific recognition protein 1; suppressor of Ty homolog-16; MECHANISMS; DORMANCY; COMPLEX;

D O I：

10.1111/jcmm.14897

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence.

引用

页码：2229 / 2239

页数：11

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