Molecular regulation of stem cell quiescence

被引：796

作者：

Cheung, Tom H. ^{[1
,2
,4
]}

Rando, Thomas A. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Sch Med, Paul F Glenn Labs Biol Aging, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[3] Vet Affairs Palo Alto Hlth Care Syst, Neurol Serv & Rehabil Res & Dev Ctr Excellence, Palo Alto, CA 94304 USA

[4] Hong Kong Univ Sci & Technol, Div Life Sci, Kowloon, Hong Kong, Peoples R China

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2013年 / 14卷 / 06期

基金：

美国国家卫生研究院;

关键词：

RNA-POLYMERASE-II; LABEL-RETAINING CELLS; IMMORTAL STRAND HYPOTHESIS; 3' UNTRANSLATED REGIONS; TEMPLATE DNA STRANDS; SELF-RENEWAL; SATELLITE CELL; MESSENGER-RNA; ALTERNATIVE POLYADENYLATION; MAINTAIN QUIESCENCE;

D O I：

10.1038/nrm3591

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of time. This state, which is reversible, has long been viewed as dormant and with minimal basal activity. Recent advances in adult stem cell isolation have provided insights into the epigenetic, transcriptional and post-transcriptional control of quiescence and suggest that quiescence is an actively maintained state in which signalling pathways are involved in maintaining a poised state that allows rapid activation. Deciphering the molecular mechanisms regulating adult stem cell quiescence will increase our understanding of tissue regeneration mechanisms and how they are dysregulated in pathological conditions and in ageing.

引用

收藏

页码：329 / 340

页数：12

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