New insights into the formation of active nonsensemediated decay complexes

被引：69

作者：

Singh, G ^{[1
]}

Lykke-Andersen, J ^{[1
]}

机构：

[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 09期

关键词：

MESSENGER-RNA SURVEILLANCE; EXON JUNCTION COMPLEX; MEDIATED DECAY; CYTOPLASMIC TRANSLATION; CAENORHABDITIS-ELEGANS; TERMINATION-CODON; MAMMALIAN-CELLS; HUMAN SMG-1; PROTEIN; INTRON;

D O I：

10.1016/S0968-0004(03)00176-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the nonsense-mediated mRNA decay (NMD) pathway, an exon-junction protein complex (EJC) and hUpf proteins mediate rapid downregulation of aberrant mRNAs that terminate translation upstream of the last splice junction. Two EJC subunits, Y14 and RNPS1, have been proposed to act as a link between splicing and NMD by recruiting hUpf3 and the other hUpf proteins. New studies now present evidence that Y14 is directly involved in NMD, and that Y14 is required for hUpf3 activity. These findings suggest unforeseen intricacies in the formation of active NMD complexes.

引用

页码：464 / 466

页数：3

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