Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration

被引：25

作者：

Weissman, SA ^{[1
]}

Lewis, S ^{[1
]}

Askin, D ^{[1
]}

Volante, RP ^{[1
]}

Reider, PJ ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(98)01670-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7459 / 7462

页数：4

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