Circulating 25-Hydroxyvitamin D and Risk of Endometrial Cancer

被引：30

作者：

Zeleniuch-Jacquotte, Anne ^{[1
,2
]}

Gallicchio, Lisa ^{[3
,4
]}

Hartmuller, Virginia ^{[5
]}

Helzlsouer, Kathy J. ^{[3
,4
]}

McCullough, Marjorie L. ^{[6
]}

Setiawan, V. Wendy ^{[7
]}

Shu, Xiao-Ou ^{[8
]}

Weinstein, Stephanie J. ^{[9
]}

Weiss, Jocelyn M. ^{[9
]}

Arslan, Alan A. ^{[1
,2
]}

De Vivo, Immaculata ^{[13
,14
]}

Gao, Yu-Tang ^{[10
]}

Hayes, Richard B. ^{[1
,2
]}

Henderson, Brian E. ^{[7
]}

Horst, Ronald L. ^{[11
]}

Koenig, Karen L. ^{[1
,2
]}

Patel, Alpa V. ^{[6
]}

Purdue, Mark P. ^{[9
]}

Snyder, Kirk ^{[12
]}

Steplowski, Emily ^{[12
]}

Yu, Kai ^{[9
]}

Zheng, Wei ^{[8
]}

Hankinson, Susan E. ^{[13
,14
,15
]}

机构：

[1] NYU, Sch Med, Dept Environm Med, New York, NY 10016 USA

[2] NYU, Sch Med, Inst Canc, New York, NY 10016 USA

[3] Mercy Med Ctr, Weinberg Ctr Womens Hlth & Med, Prevent & Res Ctr, Baltimore, MD USA

[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[5] Sci Consulting Grp Inc, Gaithersburg, MD USA

[6] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[7] Univ So Calif, Keck Sch Med, Kenneth Norris Jr Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA 90033 USA

[8] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[9] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[10] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China

[11] Heartland Assays Inc, Ames, IA USA

[12] Informat Management Serv Inc, Silver Spring, MD USA

[13] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[14] Harvard Univ, Sch Med, Boston, MA USA

[15] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2010年 / 172卷 / 01期

基金：

美国国家卫生研究院;

关键词：

case-control studies; endometrial neoplasms; prospective studies; vitamin D; VITAMIN-D; POPULATION; EXPRESSION; MORTALITY; ESTROGENS; WOMEN; DIET; US;

D O I：

10.1093/aje/kwq114

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A nested case-control study, including 830 cases and 992 controls from 7 cohorts, was conducted to evaluate the association of circulating 25-hydroxyvitamin D (25(OH)D), the best indicator of vitamin D status, with risk of endometrial cancer. Matching factors included age at blood donation, date of blood donation, and race. Conditional logistic regression was used in the main analysis. The median concentration of 25(OH)D was slightly lower in cases (49.4 nmol/L) than in controls (50.8 nmol/L) (P = 0.08). However, there was no association between 25(OH)D concentration and disease risk, after adjustment for body mass index. Compared with the 50-< 75 nmol/L 25(OH)D category, the body mass index-adjusted odds ratios and 95% confidence intervals were 1.08 (95% confidence interval: 0.73, 1.57) for the < 25 nmol/L category and 0.90 (95% confidence interval: 0.51, 1.58) for the >= 100 nmol/L category (P-trend = 0.99). Similarly null results were observed after further adjustment for other known risk factors and in stratified analyses. Although an effect of circulating 25(OH)D at high concentrations cannot be ruled out (the highest category of 25(OH)D was >= 100 nmol/L, and for stratified analyses, >= 75 nmol/L), these results do not support a protective role of vitamin D against endometrial cancer.

引用

页码：36 / 46

页数：11

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