Vaccine for Atherosclerosis

被引：91

作者：

Shah, Prediman K. ^{[1
]}

Chyu, Kuang-Yuh ^{[1
]}

Dimayuga, Paul C. ^{[1
]}

Nilsson, Jan ^{[2
]}

机构：

[1] Cedars Sinai Med Ctr, Cedars Sinai Heart Inst, Div Cardiol, Oppenheimer Atherosclerosis Res Ctr, Los Angeles, CA 90048 USA

[2] Lund Univ, Malmo Univ Hosp, Dept Clin Sci, Malmo, Sweden

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2014年 / 64卷 / 25期

关键词：

apolipoprotein B-100; atherosclerotic plaque; cardiovascular diseases; dendritic cells; low-density lipoproteins; T-lymphocytes; LOW-DENSITY-LIPOPROTEIN; E-DEFICIENT MICE; REGULATORY T-CELLS; HEAT-SHOCK PROTEIN-65; ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; PLASMACYTOID DENDRITIC CELLS; RANDOMIZED CONTROLLED-TRIAL; APOLIPOPROTEIN-E; REDUCES ATHEROSCLEROSIS;

D O I：

10.1016/j.jacc.2014.10.018

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in atherosclerosis. Hence, it is conceivable that an immunomodulatory strategy via active immunization against many of these antigens could potentially alter the natural history of atherosclerosis. This review discusses: 1) the complex role of important components of the innate and adaptive immune systems in atherogenesis; 2) the nature of many antigens that have been tested successfully in vaccine formulations to reduce atherosclerosis in pre-clinical experimental models; and 3) the potential opportunities and challenges for clinical application of vaccination for atherosclerosis in the future. (C) 2014 by the American College of Cardiology Foundation.

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收藏

页码：2779 / 2791

页数：13

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