Simulated moving bed process with cyclic modulation of the feed concentration

被引：93

作者：

Schramm, H

Kaspereit, M

Kienle, A

Seidel-Morgenstern, A

机构：

[1] Max Planck Inst Dynam Komplexer Tech Syst, D-39106 Magdeburg, Germany

[2] Univ Magdeburg, D-39106 Magdeburg, Germany

来源：

JOURNAL OF CHROMATOGRAPHY A | 2003年 / 1006卷 / 1-2期

关键词：

simulated moving bed chromatography; preparative chromatography; feed concentration gradient; cyclic modulation;

D O I：

10.1016/S0021-9673(03)00327-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The improvement of the simulated moving bed (SMB) process based on the introduction of a cyclic modulation of the feed concentration is described. It is demonstrated that such a feed concentration gradient during the shifting cycle can improve the performance significantly. The productivity and the product concentrations can be increased while simultaneously the solvent consumption can be decreased compared to the conventional SMB process with constant feed parameters. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：77 / 86

页数：10

共 19 条

[11] The "VARICOL" process: A new multicolumn continuous chromatographic process [J].