microRNAs in Psoriasis

被引：163

作者：

Hawkes, Jason E. ^{[1
]}

Nguyen, Giang Huong ^{[2
]}

Fujita, Mayumi ^{[2
]}

Florell, Scott R. ^{[1
]}

Duffin, Kristina Callis ^{[1
]}

Krueger, Gerald G. ^{[1
]}

O'Connell, Ryan M. ^{[3
]}

机构：

[1] Univ Utah, Dept Dermatol, Salt Lake City, UT 84112 USA

[2] Univ Colorado, Dept Dermatol, Aurora, CO USA

[3] Univ Utah, Dept Pathol, 4280B EEJMRB,15 North Med Dr East, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2016年 / 136卷 / 02期

关键词：

PASSENGER-STRAND; SMALL RNAS; SKIN; EXPRESSION; MIR-125B; MIR-146A; CLEAVAGE; MIR-21; GENES; SERUM;

D O I：

10.1038/JID.2015.409

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Psoriasis is a chronic inflammatory skin condition resulting from a complex interplay among the immune system, keratinocytes, susceptibility genes, and environmental factors. However, the pathogenesis of psoriasis is not completely elucidated. microRNAs represent a promising class of small, noncoding RNA molecules that function to regulate gene expression. Although microRNA research in psoriasis and dermatology is still relatively new, evidence is rapidly accumulating for the role of microRNAs in the pathogenesis of psoriasis and other chronic inflammatory conditions. In this article, we present a comprehensive review of what is known about microRNAs and their role in the pathogenesis of psoriasis.

引用

页码：365 / 371

页数：7

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