The S phase checkpoint: When the crowd meets at the fork

被引：54

作者：

Gottifredi, V

Prives, C

机构：

[1] Columbia Univ, Dept Sci Biol, New York, NY 10027 USA

[2] Consejo Nacl Invest Cient & Tecn CONICET, Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 03期

关键词：

S phase checkpoint; DNA replication; DNA damage; ATM/ATR; Chk1/Chk2;

D O I：

10.1016/j.semcdb.2005.02.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accumulation of unrepaired DNA lesions is the biggest threat to genomic stability. DNA damage checkpoints create windows of time that allow the cell to repair assaults on DNA in each phase of the cell cycle. When DNA lesions arise in S phase, however, the checkpoint machinery must work to coordinate DNA replication and repair processes. In fact some upstream components of the DNA damage checkpoint play parallel roles in maintaining the continuity of DNA replication and signaling to downstream components. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：355 / 368

页数：14

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