The dual role of the contact system in bacterial infectious disease

被引：103

作者：

Frick, Inga-Maria ^{[1
]}

Bjorck, Lars ^{[1
]}

Herwald, Heiko ^{[1
]}

机构：

[1] Lund Univ, BMC, Dept Clin Sci, Sect Clin & Expt Infect Med, SE-22184 Lund, Sweden

来源：

THROMBOSIS AND HAEMOSTASIS | 2007年 / 98卷 / 03期

关键词：

coagulation; contact system; inflammation; infectious diseases; innate immunity;

D O I：

10.1160/TH07-01-0051

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hemostasis is a sensitive and tightly regulated process, involving the vascular endothelium and blood cells as well as factors of the coagulation and fibrinolytic cascades. Over the last four decades evidence has accumulated that during infection, inflammatory mediators from the microbe and/or host are capable to modulate the equilibrium between the procoagulant and anticoagulant status of the host. Dependent on the mode of activation these changes can cause either local or systemic inflammatory, reactions that may be beneficial or deleterious to the human host. The present review aims to present the state of the art with respect to the role of the contact system (also known as the intrinsic pathway of coagulation or the kallikrein/kinin system) in innate immunity and systemic inflammatory reactions. © 2007 Schattauer GmbH, Stuttgart.

引用

页码：497 / 502

页数：6

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