The dual role of the contact system in bacterial infectious disease

被引：103

作者：

Frick, Inga-Maria ^{[1
]}

Bjorck, Lars ^{[1
]}

Herwald, Heiko ^{[1
]}

机构：

[1] Lund Univ, BMC, Dept Clin Sci, Sect Clin & Expt Infect Med, SE-22184 Lund, Sweden

来源：

THROMBOSIS AND HAEMOSTASIS | 2007年 / 98卷 / 03期

关键词：

coagulation; contact system; inflammation; infectious diseases; innate immunity;

D O I：

10.1160/TH07-01-0051

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hemostasis is a sensitive and tightly regulated process, involving the vascular endothelium and blood cells as well as factors of the coagulation and fibrinolytic cascades. Over the last four decades evidence has accumulated that during infection, inflammatory mediators from the microbe and/or host are capable to modulate the equilibrium between the procoagulant and anticoagulant status of the host. Dependent on the mode of activation these changes can cause either local or systemic inflammatory, reactions that may be beneficial or deleterious to the human host. The present review aims to present the state of the art with respect to the role of the contact system (also known as the intrinsic pathway of coagulation or the kallikrein/kinin system) in innate immunity and systemic inflammatory reactions. © 2007 Schattauer GmbH, Stuttgart.

引用

页码：497 / 502

页数：6

共 68 条

[11]

Hecquet C., Tan F., Marcic B.M., Et al., Human bradykinin B(2) receptor is activated by kallikrein and other serine proteases, Mol Pharmacol, 58, pp. 828-836, (2000)

[12]

Marceau F., Houle S., Molinaro G., Et al., Does the bradykinin B2 receptor function as a protease-activated receptor?, Hypertension, 42, (2003)

[13]

Blais Jr. C., Marceau F., Rouleau J.L., Et al., The kallikrein-kininogen-kinin system: Lessons from the quantification of endogenous kinins, Peptides, 21, pp. 1903-1940, (2000)

[14]

Kahn R., Herwald H., Muller-Esterl W., Et al., Contact-system activation in children with vasculitis, Lancet, 360, pp. 535-541, (2002)

[15]

Cassim B., Mody G., Bhoola K., Kallikrein cascade and cytokines in inflamed joints, Pharmacol Ther, 94, pp. 1-34, (2002)

[16]

Zasloff M., Antimicrobial peptides of multicellular organisms, Nature, 415, pp. 389-395, (2002)

[17]

Bevins C.L., Antimicrobial peptides as effector molecules of mammalian host defense, Contrib Microbiol, 10, pp. 106-148, (2003)

[18]

Boman H.G., Antibacterial peptides: Basic facts and emerging concepts, J Intern Med, 254, pp. 197-215, (2003)

[19]

Peschel A., Sahl H.G., The co-evolution of host cationic antimicrobial peptides and microbial resistance, Nat Rev Microbiol, 4, pp. 529-536, (2006)

[20]

Opal S.M., Esmon C.T., Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis, Crit Care, 7, pp. 23-38, (2003)

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