Interferons and apoptosis

被引：79

作者：

Clemens, MJ ^{[1
]}

机构：

[1] Univ London St Georges Hosp, Sch Med, Translat Control Grp, Dept Basic Med Sci, London SW17 0RE, England

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2003年 / 23卷 / 06期

关键词：

D O I：

10.1089/107999003766628124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interferons (IFNs), in addition to their well-known antiviral activities, have important roles in the control of cell proliferation and are effective agents for the treatment of a limited number of malignant diseases. IFNs not only regulate cell growth and division but also influence cell survival through their effects on apoptosis. This review describes the current state of knowledge about the mechanisms of action of these cytokines on the apoptotic machinery, with particular emphasis on the synergism that exists between the IFNs and other proapoptotic agents, such as members of the tumor necrosis factor (TNF) family. The review also discusses the physiologic and clinical implications of the effects of the IFNs on apoptosis for regulation of viral infection and tumor growth.

引用

页码：277 / 292

页数：16

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