共 192 条
Peripheral CD4+T-cell differentiation regulated by networks of cytokines and transcription factors
被引:433
作者:

Zhu, Jinfang
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

Paul, William E.
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA
机构:
[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA
基金:
美国国家卫生研究院;
关键词:
T-helper cells;
cytokines;
transcription factors;
T-cell differentiation;
FOLLICULAR-HELPER-CELLS;
GROWTH-FACTOR-BETA;
CD4(+) T-CELLS;
ROR-GAMMA-T;
LOCUS-CONTROL REGION;
HYPER-IGE SYNDROME;
TGF-BETA;
GENE-EXPRESSION;
TH2;
CELLS;
IN-VIVO;
D O I:
10.1111/j.1600-065X.2010.00951.x
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
CD4+ T cells, also known as T-helper (Th) cells, play an important role in orchestrating adaptive immune responses to various infectious agents. They are also involved in the induction of autoimmune and allergic diseases. Upon T-cell receptor (TCR)-mediated cell activation, naive CD4+ T cells can differentiate into at least four major lineages, Th1, Th2, Th17, and iTreg cells, that participate in different types of immune responses. Networks of cytokines and transcription factors are critical for determining CD4+ T-cell fates and effector cytokine production. Here, we review collaboration and cross-regulation between various essential cytokines in the activation/induction of key transcription factors during the process of Th cell differentiation towards these distinct lineages. We also discuss the interactions of key transcription factors at both genetic and protein levels and the function of the resulting network(s) in regulating the expression of effector cytokines.
引用
收藏
页码:247 / 262
页数:16
相关论文
共 192 条
[81]
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor α-chain expression
[J].
Liao, Wei
;
Schones, Dustin E.
;
Oh, Jangsuk
;
Cui, Yongzhi
;
Cui, Kairong
;
Roh, Tae-Young
;
Zhao, Keji
;
Leonard, Warren J.
.
NATURE IMMUNOLOGY,
2008, 9 (11)
:1288-1296

Liao, Wei
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Schones, Dustin E.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Oh, Jangsuk
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Cui, Yongzhi
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDK, Lab Genet & Physiol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Cui, Kairong
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Roh, Tae-Young
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Zhao, Keji
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Leonard, Warren J.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA
[82]
STAT1 plays a critical role in the regulation of antimicrobial effector mechanisms, but not in the development of Th1-type responses during toxoplasmosis
[J].
Lieberman, LA
;
Banica, M
;
Reiner, SL
;
Hunter, CA
.
JOURNAL OF IMMUNOLOGY,
2004, 172 (01)
:457-463

Lieberman, LA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

Banica, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

Reiner, SL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

Hunter, CA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
[83]
T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells
[J].
Lighvani, AA
;
Frucht, DM
;
Jankovic, D
;
Yamane, H
;
Aliberti, J
;
Hissong, BD
;
Nguyen, BV
;
Gadina, M
;
Sher, A
;
Paul, WE
;
O'Shea, JJ
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2001, 98 (26)
:15137-15142

Lighvani, AA
论文数: 0 引用数: 0
h-index: 0
机构: US FDA, Ctr Biol Evaluat & Res, Cell Biol Lab, Bethesda, MD 20892 USA

Frucht, DM
论文数: 0 引用数: 0
h-index: 0
机构: US FDA, Ctr Biol Evaluat & Res, Cell Biol Lab, Bethesda, MD 20892 USA

Jankovic, D
论文数: 0 引用数: 0
h-index: 0
机构: US FDA, Ctr Biol Evaluat & Res, Cell Biol Lab, Bethesda, MD 20892 USA

Yamane, H
论文数: 0 引用数: 0
h-index: 0
机构: US FDA, Ctr Biol Evaluat & Res, Cell Biol Lab, Bethesda, MD 20892 USA

Aliberti, J
论文数: 0 引用数: 0
h-index: 0
机构: US FDA, Ctr Biol Evaluat & Res, Cell Biol Lab, Bethesda, MD 20892 USA

Hissong, BD
论文数: 0 引用数: 0
h-index: 0
机构: US FDA, Ctr Biol Evaluat & Res, Cell Biol Lab, Bethesda, MD 20892 USA

Nguyen, BV
论文数: 0 引用数: 0
h-index: 0
机构: US FDA, Ctr Biol Evaluat & Res, Cell Biol Lab, Bethesda, MD 20892 USA

Gadina, M
论文数: 0 引用数: 0
h-index: 0
机构: US FDA, Ctr Biol Evaluat & Res, Cell Biol Lab, Bethesda, MD 20892 USA

Sher, A
论文数: 0 引用数: 0
h-index: 0
机构: US FDA, Ctr Biol Evaluat & Res, Cell Biol Lab, Bethesda, MD 20892 USA

Paul, WE
论文数: 0 引用数: 0
h-index: 0
机构: US FDA, Ctr Biol Evaluat & Res, Cell Biol Lab, Bethesda, MD 20892 USA

O'Shea, JJ
论文数: 0 引用数: 0
h-index: 0
机构: US FDA, Ctr Biol Evaluat & Res, Cell Biol Lab, Bethesda, MD 20892 USA
[84]
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells
[J].
Lochner, Matthias
;
Peduto, Lucie
;
Cherrier, Marie
;
Sawa, Shinichiro
;
Langa, Francina
;
Varona, Rosa
;
Riethmacher, Dieter
;
Si-Tahar, Mustapha
;
Di Santo, James P.
;
Eberl, Gerard
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2008, 205 (06)
:1381-1393

论文数: 引用数:
h-index:
机构:

Peduto, Lucie
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France

Cherrier, Marie
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France

Sawa, Shinichiro
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France

Langa, Francina
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Ctr Ingn Genet Murine, F-75724 Paris, France Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France

Varona, Rosa
论文数: 0 引用数: 0
h-index: 0
机构:
CSIC, Dept Immunol & Oncol, Ctr Nacl Biotecnol, E-28049 Madrid, Spain Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

Di Santo, James P.
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Unite Cytokines & Dev Lymphoide, INSERM, U668, F-75724 Paris, France Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France

Eberl, Gerard
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France
[85]
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4
[J].
Lohoff, M
;
Mittrücker, HW
;
Prechtl, S
;
Bischof, S
;
Sommer, F
;
Kock, S
;
Ferrick, DA
;
Duncan, GS
;
Gessner, A
;
Mak, TW
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2002, 99 (18)
:11808-11812

Lohoff, M
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Res Inst, Dept Immunol, Toronto, ON, Canada

Mittrücker, HW
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Res Inst, Dept Immunol, Toronto, ON, Canada

Prechtl, S
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Res Inst, Dept Immunol, Toronto, ON, Canada

Bischof, S
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Res Inst, Dept Immunol, Toronto, ON, Canada

Sommer, F
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Res Inst, Dept Immunol, Toronto, ON, Canada

Kock, S
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Res Inst, Dept Immunol, Toronto, ON, Canada

Ferrick, DA
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Res Inst, Dept Immunol, Toronto, ON, Canada

Duncan, GS
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Res Inst, Dept Immunol, Toronto, ON, Canada

Gessner, A
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Res Inst, Dept Immunol, Toronto, ON, Canada

Mak, TW
论文数: 0 引用数: 0
h-index: 0
机构:
Amgen Res Inst, Dept Immunol, Toronto, ON, Canada Amgen Res Inst, Dept Immunol, Toronto, ON, Canada
[86]
Mast cells are essential intermediaries in regulatory T-cell tolerance
[J].
Lu, Li-Fan
;
Lind, Evan F.
;
Gondek, David C.
;
Bennett, Kathy A.
;
Gleeson, Michael W.
;
Pino-Lagos, Karina
;
Scott, Zachary A.
;
Coyle, Anthony J.
;
Reed, Jennifer L.
;
Van Snick, Jacques
;
Strom, Terry B.
;
Zheng, Xin Xiao
;
Noelle, Randolph J.
.
NATURE,
2006, 442 (7106)
:997-1002

Lu, Li-Fan
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Lind, Evan F.
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Gondek, David C.
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Bennett, Kathy A.
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Gleeson, Michael W.
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Pino-Lagos, Karina
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Scott, Zachary A.
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Coyle, Anthony J.
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Reed, Jennifer L.
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Van Snick, Jacques
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Strom, Terry B.
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Zheng, Xin Xiao
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

Noelle, Randolph J.
论文数: 0 引用数: 0
h-index: 0
机构: Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA
[87]
Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells
[J].
Makar, KW
;
Pérez-Melgosa, M
;
Shnyreva, M
;
Weaver, WM
;
Fitzpatrick, DR
;
Wilson, CB
.
NATURE IMMUNOLOGY,
2003, 4 (12)
:1183-1190

Makar, KW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Immunol, Seattle, WA 98195 USA

Pérez-Melgosa, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Immunol, Seattle, WA 98195 USA

Shnyreva, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Immunol, Seattle, WA 98195 USA

Weaver, WM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Immunol, Seattle, WA 98195 USA

Fitzpatrick, DR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Immunol, Seattle, WA 98195 USA

Wilson, CB
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Immunol, Seattle, WA 98195 USA Univ Washington, Dept Immunol, Seattle, WA 98195 USA
[88]
Transforming growth factor-β induces development of the TH17 lineage
[J].
Mangan, PR
;
Harrington, LE
;
O'Quinn, DB
;
Helms, WS
;
Bullard, DC
;
Elson, CO
;
Hatton, RD
;
Wahl, SM
;
Schoeb, TR
;
Weaver, CT
.
NATURE,
2006, 441 (7090)
:231-234

Mangan, PR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

Harrington, LE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

O'Quinn, DB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

Helms, WS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

Bullard, DC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

Elson, CO
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

Hatton, RD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

Wahl, SM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

Schoeb, TR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

Weaver, CT
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA
[89]
Molecular mechanisms underlying FOXP3 induction in human T cells
[J].
Mantel, Pierre-Yves
;
Ouaked, Nadia
;
Ruckert, Beate
;
Karagiannidis, Christian
;
Welz, Roland
;
Blaser, Kurt
;
Schmidt-Weber, Carsten B.
.
JOURNAL OF IMMUNOLOGY,
2006, 176 (06)
:3593-3602

Mantel, Pierre-Yves
论文数: 0 引用数: 0
h-index: 0
机构:
Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland

Ouaked, Nadia
论文数: 0 引用数: 0
h-index: 0
机构:
Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland

Ruckert, Beate
论文数: 0 引用数: 0
h-index: 0
机构:
Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland

Karagiannidis, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland

Welz, Roland
论文数: 0 引用数: 0
h-index: 0
机构:
Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland

Blaser, Kurt
论文数: 0 引用数: 0
h-index: 0
机构:
Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland

Schmidt-Weber, Carsten B.
论文数: 0 引用数: 0
h-index: 0
机构:
Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland
[90]
Stat3 and Stat4 direct development of IL-17-secreting Th cells
[J].
Mathur, Anubhav N.
;
Chang, Hua-Chen
;
Zisoulis, Dimitrios G.
;
Stritesky, Gretta L.
;
Yu, Qing
;
O'Malley, John T.
;
Kapur, Reuben
;
Levy, David E.
;
Kansas, Geoffrey S.
;
Kaplan, Mark H.
.
JOURNAL OF IMMUNOLOGY,
2007, 178 (08)
:4901-4907

Mathur, Anubhav N.
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

Chang, Hua-Chen
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

Zisoulis, Dimitrios G.
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

Stritesky, Gretta L.
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

Yu, Qing
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

O'Malley, John T.
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

Kapur, Reuben
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

Levy, David E.
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

Kansas, Geoffrey S.
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

Kaplan, Mark H.
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA