Peripheral CD4+T-cell differentiation regulated by networks of cytokines and transcription factors

被引:433
作者
Zhu, Jinfang [1 ]
Paul, William E. [1 ]
机构
[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
T-helper cells; cytokines; transcription factors; T-cell differentiation; FOLLICULAR-HELPER-CELLS; GROWTH-FACTOR-BETA; CD4(+) T-CELLS; ROR-GAMMA-T; LOCUS-CONTROL REGION; HYPER-IGE SYNDROME; TGF-BETA; GENE-EXPRESSION; TH2; CELLS; IN-VIVO;
D O I
10.1111/j.1600-065X.2010.00951.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CD4+ T cells, also known as T-helper (Th) cells, play an important role in orchestrating adaptive immune responses to various infectious agents. They are also involved in the induction of autoimmune and allergic diseases. Upon T-cell receptor (TCR)-mediated cell activation, naive CD4+ T cells can differentiate into at least four major lineages, Th1, Th2, Th17, and iTreg cells, that participate in different types of immune responses. Networks of cytokines and transcription factors are critical for determining CD4+ T-cell fates and effector cytokine production. Here, we review collaboration and cross-regulation between various essential cytokines in the activation/induction of key transcription factors during the process of Th cell differentiation towards these distinct lineages. We also discuss the interactions of key transcription factors at both genetic and protein levels and the function of the resulting network(s) in regulating the expression of effector cytokines.
引用
收藏
页码:247 / 262
页数:16
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