TRP-ing up melanophores: TRPM7, melanin synthesis, and pigment cell survival

被引：9

作者：

Iuga, Aurel O. ^{[1
]}

Lerner, Ethan A. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2007年 / 127卷 / 08期

关键词：

D O I：

10.1038/sj.jid.5700773

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

McNeill et al. (2007, this issue) dissect the potential role of TRPM7 ion channels in pigment cells by studying the phenotype of zebrafish trpm7 mutant embryos. They demonstrate that 1-phenyl-2-thiourea, a known melanin synthesis inhibitor, prevents melanophore cell death in these mutants. This suggests a potential functional link between TRPM7 signaling and the detoxification of melanin synthesis intermediates.

引用

页码：1855 / 1856

页数：2

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