Natural product-like combinatorial libraries

被引：39

作者：

Abreu, PM ^{[1
]}

Branco, PS ^{[1
]}

机构：

[1] Univ Nova Lisboa, FCT, Ctr Quim Fina & Biotecnol, Dept Quim, P-2829516 Caparica, Portugal

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2003年 / 14卷 / 05期

关键词：

natural products; combinatorial chemistry; drug discovery; lead compounds;

D O I：

10.1590/S0103-50532003000500002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a challenge to combinatorial strategies for natural products synthesis and derivatization. This article surveys the application of combinatorial techniques to the design of "natural product-looking" libraries covering a wide range of structural diversities.

引用

页码：675 / 712

页数：38

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