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Annonaceous acetogenins: Recent progress

被引：745
作者：
Alali, FQ [1 ]
Liu, XX [1 ]
McLaughlin, JL [1 ]
机构：
[1] Purdue Univ, Sch Pharm & Pharmacal Sci, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 03期
关键词：
D O I：
10.1021/np980406d
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995.
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页码：504 / 540
页数：37
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