Annonaceous acetogenins: Recent progress

被引：745

作者：

Alali, FQ ^{[1
]}

Liu, XX ^{[1
]}

McLaughlin, JL ^{[1
]}

机构：

[1] Purdue Univ, Sch Pharm & Pharmacal Sci, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 03期

关键词：

D O I：

10.1021/np980406d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995.

引用

页码：504 / 540

页数：37

共 143 条

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