Muricadienin, muridienins and chatenaytrienins, the early precursors of annonaceous acetogenins

被引：43

作者：

Gleye, C

Raynaud, S

Hocquemiller, R

Laurens, A

Fourneau, C

Serani, L

Laprévote, O

Roblot, F

Leboeuf, M

Fournet, A

De Arias, AR

Figadère, B

Cavé, A

机构：

[1] Univ Paris Sud, Fac Pharm, URA 1843 CNRS, BIOCIS,Lab Pharmacognosie, F-92296 Chatenay Malabry, France

[2] CNRS, Inst Chim Subst Nat, Lab Spectrometrie Masse, F-91198 Gif Sur Yvette, France

[3] IICS, Asuncion, Paraguay

来源：

PHYTOCHEMISTRY | 1998年 / 47卷 / 05期

关键词：

Annona muricata; A-nutans; Annonaceae; acetogenins; oxidative degradation; enzymatic oxidation; tris-unsaturated fatty acid derivatives; biogenetic pathway;

D O I：

10.1016/S0031-9422(97)00908-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chatenaytrienins-1,-2 and -3, muridienins-3 and -4 and muricadienin were characterized by tandem mass spectrometry (MS/MS) in a mixture of natural precursors of annonaceous acetogenins from Annona muricata. Chatenaytrienin-1, -2, -3 and -4 were then isolated from A. nutans and fully characterized by spectroscopic methods (NMR, MS) and by chemical and enzymatic oxidative processes. Isolation of these trienes confirmed the postulated biosynthetic pathway leading to the acetogenins. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

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页码：749 / 754

页数：6

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