WNT1 inducible signaling pathway protein 1 (WISP1): A novel mediator linking development and disease

被引：111

作者：

Berschneider, Barbara

Koenigshoff, Melanie ^{[1
]}

机构：

[1] Univ Munich, Comprehens Pneumol Ctr, Univ Hosp Grosshadem, D-81377 Munich, Germany

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2011年 / 43卷 / 03期

关键词：

WISP1; CCN; Matricellular protein; Fibrosis; TISSUE GROWTH-FACTOR; IDIOPATHIC PULMONARY-FIBROSIS; INDUCED CARDIOMYOCYTE DEATH; SECRETED PROTEIN-1; CELL-LINES; EXPRESSION; GENES; ACTIVATION; BIGLYCAN; LUNG;

D O I：

10.1016/j.biocel.2010.11.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

WISP1 is a secreted, matricellular protein allocated to the CCN protein family. The CCN protein family consists of six, modular structured, secreted proteins. WISP1 is mainly expressed during organ development and under diseased conditions, such as fibrosis or cancer. Its expression is associated with proliferation, cytoprotection, as well as extracellular matrix production, thereby representing a highly attractive therapeutical target for future applications. (C) 2010 Elsevier Ltd. All rights reserved.

引用

收藏

页码：306 / 309

页数：4

相关论文

共 30 条

[1]

Involvement of the Wnt Signaling Pathway in Experimental and Human Osteoarthritis Prominent Role of Wnt-Induced Signaling Protein 1 [J].

Blom, Arjen B. ;

Brockbank, Sarah M. ;

van Lent, Peter L. ;

van Beuningen, Henk M. ;

Geurts, Jeroen ;

Takahashi, Nozomi ;

van der Kraan, Peter M. ;

van de Loo, Fons A. ;

Schreurs, B. Wim ;

Clements, Kristen ;

Newham, Peter ;

van den Berg, Wim B. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (02) :501-512

[2]

Proposal for a unified CCN nomenclature [J].

Brigstock, DR ;

Goldschmeding, R ;

Katsube, K ;

Lam, SCT ;

Lau, LF ;

Lyons, K ;

Naus, C ;

Perbal, B ;

Riser, B ;

Takigawa, M ;

Yeger, H .

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 2003, 56 (02) :127-128

[3]

Activation of the canonical Wnt/β-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer [J].

Calvisi, DF ;

Conner, EA ;

Ladu, S ;

Lemmer, ER ;

Factor, VM ;

Thorgeirsson, SS .

JOURNAL OF HEPATOLOGY, 2005, 42 (06) :842-849

[4]

Functions and mechanisms of action of CCN matricellular proteins [J].

Chen, Chih-Chiun ;

Lau, Lester F. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 41 (04) :771-783

[5]

Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor [J].

Colston, J. T. ;

de la Rosa, S. D. ;

Koehler, M. ;

Gonzales, K. ;

Mestril, R. ;

Freeman, G. L. ;

Bailey, S. R. ;

Chandrasekar, B. .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (03) :H1839-H1846

[6]

WISP-1 binds to decorin and biglycan [J].

Desnoyers, L ;

Arnott, D ;

Pennica, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (50) :47599-47607

[7]

WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair [J].

French, DM ;

Kaul, RJ ;

D'Souza, AL ;

Crowley, CW ;

Bao, M ;

Frantz, GD ;

Filvaroff, EH ;

Desnoyers, L .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 165 (03) :855-867

[8]

Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses in vivo tumor growth and metastasis of K-1735 murine melanoma cells [J].

Hashimoto, Y ;

Shindo-Okada, N ;

Tani, M ;

Nagamachi, Y ;

Takeuchi, K ;

Shiroishi, T ;

Toma, H ;

Yokota, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (03) :289-296

[9]

TGF-β1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast function [J].

Inkson, Colette A. ;

Ono, Mitsuaki ;

Kuznetsov, Sergei A. ;

Fisher, Larry W. ;

Robey, Pamela Gehron ;

Young, Marian F. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2008, 104 (05) :1865-1878

[10]

The Potential Functional Interaction of Biglycan and WISP-1 in Controlling Differentiation and Proliferation of Osteogenic Cells [J].

Inkson, Colette A. ;

Ono, Mitsuaki ;

Bi, Yanming ;

Kuznetsov, Sergei A. ;

Fisher, Larry W. ;

Young, Marian F. .

CELLS TISSUES ORGANS, 2009, 189 (1-4) :153-157