Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

被引：24

作者：

Svensen, Nina ^{[1
]}

Diaz-Mochon, Juan Jose ^{[1
]}

Dhaliwal, Kevin ^{[2
]}

Planonth, Songsak ^{[1
]}

Dewar, Michael ^{[3
]}

Armstrong, J. Douglas ^{[3
]}

Bradley, Mark ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

[2] Univ Edinburgh, MRC Ctr Inflammat Res, Edinburgh EH16 4SA, Midlothian, Scotland

[3] Univ Edinburgh, Sch Informat, Edinburgh EH8 9AB, Midlothian, Scotland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 27期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

drug delivery; homing peptides; microarrays; peptide nucleic acids; peptides; PENETRATING-PEPTIDE; PHENOTYPIC HETEROGENEITY; FLOW-CYTOMETRY; TAT PEPTIDE; CELLS; GENE; LINE;

D O I：

10.1002/anie.201101804

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To the point: The identification of peptides to optimize both the delivery and tumor penetration of existing cancer drugs in a cell-selective manner would be highly desirable. The screening of a peptide nucleic acid (PNA)-encoded peptide library (see picture) now allows the identification of versatile cell homing peptides for any cell type of interest. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6133 / 6136

页数：4

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