A critical appraisal of brown adipose tissue metabolism in humans

被引：21

作者：

Blondin, Denis P. ^{[1
]}

Labbe, Sebastien M. ^{[2
]}

Turcotte, Eric E. ^{[3
]}

Haman, Francois ^{[4
]}

Richard, Denis ^{[2
]}

Carpentier, Andre C. ^{[1
]}

机构：

[1] Univ Sherbrooke, Div Endocrinol, Dept Med, Ctr Rech,Ctr Hosp Univ Sherbrooke, Sherbrooke, PQ J1K 2R1, Canada

[2] Univ Laval, Quebec Heart & Lung Res Inst, Quebec City, PQ, Canada

[3] Univ Sherbrooke, Dept Nucl Med & Radiobiol, Ctr Rech, Ctr Hosp Univ Sherbrooke, Sherbrooke, PQ J1K 2R1, Canada

[4] Univ Ottawa, Fac Hlth Sci, Ottawa, ON, Canada

来源：

CLINICAL LIPIDOLOGY | 2015年 / 10卷 / 03期

关键词：

brown adipose tissue; cold exposure; energy metabolism; glucose metabolism; insulin resistance; lipid metabolism; nonesterified fatty acids; Type; 2; diabetes; DIET-INDUCED THERMOGENESIS; COLD-INDUCED THERMOGENESIS; AGE-RELATED-CHANGES; ENERGY-BALANCE; PPAR-GAMMA; LIPOPROTEIN-LIPASE; ACTIVE BROWN; FAT-CELLS; NONSHIVERING THERMOGENESIS; ADAPTIVE THERMOGENESIS;

D O I：

10.2217/CLP.15.14

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of brown adipose tissue (BAT) in adult humans has been rediscovered through the clinical use of the radioactive glucose analog F-18-fluorodeoxyglucose with PET. This has led to numerous studies demonstrating cold exposure as the major physiological modulator of BAT activity. These reports also suggested that age, gender, BMI and the presence of diabetes are also important modulators of BAT volume and metabolic activity. Although F-18-fluorodeoxyglucose PET has provided important information on BAT glucose metabolism, other techniques are being developed and applied to assess other aspects of BAT metabolism. Here, we summarize the current understanding of the pathophysiological functions of BAT in humans and discuss some of the strengths and limitations of the current investigational techniques.

引用

页码：259 / 280

页数：22

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