A first case of meningitis/encephalitis associated with SARS-Coronavirus-2

被引：1358

作者：

Moriguchi, Takeshi ^{[1
]}

Harii, Norikazu ^{[2
]}

Goto, Junko ^{[1
]}

Harada, Daiki ^{[1
]}

Sugawara, Hisanori ^{[1
]}

Takamino, Junichi ^{[1
]}

Ueno, Masateru ^{[1
]}

Sakata, Hiroki ^{[1
]}

Kondo, Kengo ^{[1
]}

Myose, Natsuhiko ^{[1
]}

Nakao, Atsuhito ^{[3
]}

Takeda, Masayuki ^{[4
]}

Haro, Hirotaka ^{[5
]}

Inoue, Osamu ^{[6
]}

Suzuki-Inoue, Katsue ^{[7
]}

Kubokawa, Kayo ^{[8
]}

Ogihara, Shinji ^{[9
]}

Sasaki, Tomoyuki ^{[7
]}

Kinouchi, Hiroyuki ^{[10
]}

Kojin, Hiroyuki ^{[11
]}

Ito, Masami ^{[11
]}

Onishi, Hiroshi ^{[12
]}

Shimizu, Tatsuya ^{[12
]}

Sasaki, Yu ^{[12
]}

Enomoto, Nobuyuki ^{[13
]}

Ishihara, Hiroshi ^{[14
]}

Furuya, Shiomi ^{[11
]}

Yamamoto, Tomoko ^{[11
]}

Shimada, Shinji ^{[15
]}

机构：

[1] Univ Yamanashi, Dept Emergency & Crit Care Med, Fac Med, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[2] Univ Yamanashi, Dept Community & Family Med, Fac Med, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[3] Univ Yamanashi, Fac Med, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[4] Univ Yamanashi, Grad Sch Med Sci, Dept Urol, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[5] Univ Yamanashi, Dept Orthopaed Surg, Fac Med, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[6] Univ Yamanashi Hosp, Div Infect Control & Prevent, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[7] Univ Yamanashi, Dept Clin & Lab Med, Fac Med, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[8] Univ Yamanashi Hosp, Dept Nursing, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[9] Univ Yamanashi Hosp, Cent Lab Unit, Div Infect Control & Prevent, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[10] Univ Yamanashi, Dept Neurosurg, Fac Med, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[11] Univ Yamanashi Hosp, Dept Clin Qual & Med Safety Management, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[12] Univ Yamanashi, Dept Radiol, Fac Med, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[13] Univ Yamanashi, Dept Internal Med 1, Fac Med, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[14] Univ Yamanashi, Dept Internal Med 2, Fac Med, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[15] Univ Yamanashi, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2020年 / 94卷

关键词：

SARS-CoV-2; COVID-19; Meningitis; Infections; Polymerase chain reaction; CORONAVIRUS;

D O I：

10.1016/j.ijid.2020.03.062

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Novel coronavirus (SARS-Coronavirus-2:SARS-CoV-2) which emerged in Wuhan, China, has spread to multiple countries rapidly. We report the first case of meningitis associated with SARS-CoV-2 who was brought in by ambulance due to a convulsion accompanied by unconsciousness. He had never been to any foreign countries. He felt generalized fatigue and fever(day 1). He saw doctors near by twice (day 2 and 5) and was prescribed Laninamivir and antipyretic agents, His family visited his home and found that he was unconsciousness and lying on the floor in his vomit. He was immediately transported to this hospital by ambulance (day 9). Under emergency transport, he had transient generalized seizures that lasted about a minute. He had obvious neck stiffness. The specific SARS-CoV-2 RNA was not detected in the nasopharyngeal swab but was detected in a CSF. Anti-HSV 1 and varicella-zoster IgM antibodies were not detected in serum samples. A brain MRI showed hyperintensity along the wall of right lateral ventricle and hyperintense signal changes in the right mesial temporal lobe and hippocampus, suggesting the possibility of SARS-CoV-2 meningitis. This case warns the physicians of patients who have CNS symptoms. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：55 / 58

页数：4

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