Paradigm lost: how parasite control may alter pattern and process in human helminthiases

被引：21

作者：

Basanez, Maria-Gloria ^{[1
]}

French, Michael D. ^{[1
,2
]}

Walker, Martin ^{[1
]}

Churcher, Thomas S. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Fac Med, Dept Infect Dis Epidemiol, London W2 1PG, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, Schistosomiasis Control Initiat, London W2 1PG, England

来源：

TRENDS IN PARASITOLOGY | 2012年 / 28卷 / 04期

基金：

英国惠康基金;

关键词：

SOIL-TRANSMITTED HELMINTHIASIS; DENSITY-DEPENDENT FECUNDITY; ASCARIS-LUMBRICOIDES; LYMPHATIC FILARIASIS; ONCHOCERCA-VOLVULUS; SCHISTOSOMA-MANSONI; POPULATION BIOLOGY; BANCROFTIAN FILARIASIS; PRAZIQUANTEL TREATMENT; POTENTIAL IMPACT;

D O I：

10.1016/j.pt.2012.02.004

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Knowledge of pattern and process in helminth population biology is mostly based on the endemic equilibrium state that characterise; infections before control. Current large-scale intervention programmes aim at controlling/eliminating helminth infection, transmission and morbidity. As a result, age-infection profiles will be modified; immune responses will be affected; underlying parasite distributions may become more aggregated; density-dependent regulatory processes will relax; and the contribution to transmission and morbidity of different host population groups will shift. There is an urgent need to understand how the paradigm that has guided parasite population biology research is changing under chemotherapy-based control programmes for this research to continue supporting parasite control efforts effectively.

引用

页码：161 / 171

页数：11

共 90 条

[21] Density dependence and the spread of anthelmintic resistance [J].