Enzymatic fucosylations with purine-diphosphate-fucoses (PDP-fucoses)

被引：13

作者：

Baisch, G ^{[1
]}

Ohrlein, R ^{[1
]}

Katopodis, A ^{[1
]}

机构：

[1] CIBA GEIGY AG, CENT RES LABS, CH-4002 BASEL, SWITZERLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(96)00543-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two cloned fucosyltransferases, Fuc-t III and Fuc-t VI, are probed on a preparative scale with non-natural donor-substrates, in which the guanosine of the natural donor guanosine diphosphate-fucose is replaced by other purines, Surprisingly, the novel purine-diphosphate-fucoses (PDP-Fuc) are recognized by both enzymes as donor-substrates. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2953 / 2956

页数：4