Copper-Catalyzed Di- and Trifluoromethylation of α,β-Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations

被引:224
作者
He, Zhengbiao [1 ]
Luo, Tao [1 ]
Hu, Mingyou [1 ]
Cao, Yanjing [1 ]
Hu, Jinbo [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
基金
中国国家自然科学基金;
关键词
carboxylic acids; copper; fluorine; stereoselectivity; synthetic methods; NUCLEOPHILIC TRIFLUOROMETHYLATION; BORONIC ACIDS; REAGENT; FLUORINE; ETHERS; ARYL; (PHENYLSULFONYL)DIFLUOROMETHYLATION; PERFLUOROALKYLATION; ALKENES; SALTS;
D O I
10.1002/anie.201200140
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Dual action: The Lewis acid CuF 2·2 H 2O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,β-unsaturated carboxylic acids by dually activating both reactants, thus affording di- and trifluoromethyl alkenes in high yields with excellent E/Z selectivity. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:3944 / 3947
页数:4
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