Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues

被引：134

作者：

Pei, XH

Xiong, Y ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Program Mol Biol & Biotechnol, Chapel Hill, NC 27599 USA

来源：

ONCOGENE | 2005年 / 24卷 / 17期

关键词：

p16; p21; cyclin; CDK; CDK inhibitor; PCNA;

D O I：

10.1038/sj.onc.1208611

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

p21 and p16, first identified as two small molecular weight proteins in CDK and cyclin immunocomplexes, represent two distinct families constituting a total of seven CDK inhibitors in mammalian cells. The physiological functions of these genes are believed to be broadly involved in connecting various cellular pathways to cell cycle control. Extensive studies over the past 10 years have led to a fairly clear understanding of their biochemical and cellular mechanisms and have also left some unresolved and controversial issues.

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收藏

页码：2787 / 2795

页数：9

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