Genetic heterogeneity of hepatitis C virus - The clinical significance of genotypes and quasispecies behavior

被引：15

作者：

Marrone, A ^{[1
]}

Sallie, R ^{[1
]}

机构：

[1] NATL INST HLTH, LIVER DIS SECT, BETHESDA, MD USA

来源：

CLINICS IN LABORATORY MEDICINE | 1996年 / 16卷 / 02期

关键词：

D O I：

10.1016/S0272-2712(18)30278-6

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Knowledge of the molecular biology of the hepatitis C virus (HCV) has increased exponentially since its identification in 1989. Paradoxically, the understanding of many clinical aspects of HCV pathobiology has lagged behind, partly because of lack of suitable models of disease. The genomic variability of HCV is central to viral pathogenesis. This article briefly reviews some clinical and laboratory aspects of HCV variability, such as investigatory method, pitfalls in data interpretation, and possible directions for future research. The profound implications of stable quasispecies behavior, conserved genotype replication, and the unexpectedly low frequency of infection with multiple genotypes in susceptible individuals are discussed.

引用

页码：429 / +

页数：1

共 75 条

[61] SEQUENCE VARIABILITY IN THE 5' NONCODING REGION OF HEPATITIS-C VIRUS - IDENTIFICATION OF A NEW VIRUS TYPE AND RESTRICTIONS ON SEQUENCE DIVERSITY [J].