Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model

被引：66

作者：

Sanchís, D

Busquets, S

Alvarez, B

Ricquier, D

López-Soriano, FJ

Argilés, JM

机构：

[1] Univ Barcelona, Fac Biol, Unitat B, Dept Bioquim & Biol Mol, Barcelona 08071, Spain

[2] CNRS, UPR 9078, F-992190 Meudon, France

来源：

FEBS LETTERS | 1998年 / 436卷 / 03期

关键词：

thermogenesis; tumour growth; skeletal muscle; uncoupling protein-2; uncoupling protein-3; gene expression;

D O I：

10.1016/S0014-5793(98)01178-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rats bearing the Yoshida AH-130 ascites hepatoma showed an increased expression of both uncoupling protein-2 (UCP2) (194%) and UCP3 (189%) mRNA levels in skeletal muscle 7 days after tumour inoculation, Interestingly, an even greater increase was observed in mRNA for both UCP2 (278%) and UCP3 (797%) in the pair-fed animals, suggesting that the increase in gene expression was the result of the anorexia associated with tumour burden. The results constitute the first report of UCP2 and UCP3 gene expression during cancer cachexia and agree to their possible role in the increase of energy expenditure associated with tumour growth, (C) 1998 Federation of European Biochemical Societies.

引用

页码：415 / 418

页数：4

共 28 条

[1]

Argiles JM, 1997, MED RES REV, V17, P477, DOI 10.1002/(SICI)1098-1128(199709)17:5<477::AID-MED3>3.3.CO

[2]

2-Q

[3]

BECK SA, 1991, CANCER RES, V51, P6089

[4] INCREASED BROWN ADIPOSE-TISSUE ACTIVITY IN CHILDREN WITH MALIGNANT DISEASE [J].