Gefitinib ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, mediates the inhibition of lymph node metastasis in oral cancer cells

被引：41

作者：

Shintani, S ^{[1
]}

Li, CN ^{[1
]}

Mihara, M ^{[1
]}

Nakashiro, K ^{[1
]}

Hamakawa, H ^{[1
]}

机构：

[1] Ehime Univ, Sch Med, Dept Oral & Maxillofacial Surg, Shigenobu, Ehime 7910295, Japan

来源：

CANCER LETTERS | 2003年 / 201卷 / 02期

关键词：

epidermal growth factor receptor; tyrosine kinase inhibitor; lymph node metastasis; oral squamous cell carcinoma;

D O I：

10.1016/S0304-3835(03)00464-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High expression of epidermal growth factor receptor (EGFR) is frequently observed in many solid tumor types including oral squamous cell carcinomas (OSCC). This study investigated whether treatment with gefitinib ('Iressa'), an EGFR-tyrosine kinase inhibitor, would inhibit the metastatic spread in OSCC cells. This was evaluated using orthotopic xenografts of highly metastatic OSCC. Metastasis was observed in six of 13 gefitinib treated animals (46.2%), compared with all of 12 control animals (100%). After exposure to gefitinib, OSCC cells showed a marked reduction in cell adhesion ability to fibronectin and in the expression of integrin alpha3, alphav, beta1, beta4, beta5 and beta6. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：149 / 155

页数：7

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