The relevance of EMT in breast cancer metastasis: Correlation or causality?

被引：236

作者：

Bill, Ruben ^{[1
]}

Christofori, Gerhard ^{[1
]}

机构：

[1] Univ Basel, Dept Biomed, CH-4058 Basel, Switzerland

来源：

FEBS LETTERS | 2015年 / 589卷 / 14期

基金：

欧盟第七框架计划; 瑞士国家科学基金会;

关键词：

Breast cancer; Cell migration; Epithelial to mesenchymal transition; Metastasis; Mouse model; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-CELL INVASION; MAMMARY-CARCINOMA; E-CADHERIN; PROMOTES METASTASIS; COLLECTIVE INVASION; GENETIC ALTERATIONS; AMEBOID TRANSITION; MASTER REGULATOR; MOUSE MODELS;

D O I：

10.1016/j.febslet.2015.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Although major progress has been achieved in treating breast cancer patients, metastatic breast cancer still remains a deadly disease. A full understanding of the process of systemic cancer cell dissemination is therefore critical to develop next generation therapies. A plethora of experimental data points toward a central role of an epithelial to mesenchymal transition (EMT) in the multistep cascade of metastasis formation. However, in patients the data are based on correlative studies which often, but not always, tie the expression of EMT markers to cancer invasion, metastasis and poor clinical outcome. Moreover, the notion that cancer cells are able to switch between different modes of migration asks for a thorough review of the actual relevance of EMT in cancer metastasis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：1577 / 1587

页数：11

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