Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

被引:773
作者
Angela Nieto, M. [1 ]
机构
[1] UMH, CSIC, Inst Neurociencias, Alacant 03550, Spain
基金
欧洲研究理事会;
关键词
NEGATIVE FEEDBACK LOOP; MESENCHYMAL TRANSITION; STEM-CELLS; TUMOR PROGRESSION; METASTASIS; SNAIL; EMT; INITIATION; EXPRESSION; FIBROSIS;
D O I
10.1126/science.1234850
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
During embryonic development, many cells are born far from their final destination and must travel long distances. To become motile and invasive, embryonic epithelial cells undergo a process of mesenchymal conversion known as epithelial-to-mesenchymal transition (EMT). Likewise, EMT can be seen in cancer cells as they leave the primary tumor and disseminate to other parts of the body to colonize distant organs and form metastases. In addition, through the reverse process (mesenchymal-to-epithelial transition), both normal and carcinoma cells revert to the epithelial phenotype to, respectively, differentiate into organs or form secondary tumors. The parallels in phenotypic plasticity in normal morphogenesis and cancer highlight the importance of studying the embryo to understand tumor progression and to aid in the design of improved therapeutic strategies.
引用
收藏
页码:708 / +
页数:8
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