The ZEB/miR-200 feedback loop-a motor of cellular plasticity in development and cancer?

被引：655

作者：

Brabletz, Simone ^{[1
]}

Brabletz, Thomas ^{[1
,2
]}

机构：

[1] Univ Freiburg, Dept Visceral Surg, D-79106 Freiburg, Germany

[2] Univ Freiburg, Comprehens Canc Ctr Freiburg, D-79106 Freiburg, Germany

来源：

EMBO REPORTS | 2010年 / 11卷 / 09期

关键词：

ZEB1; miR-200; EMT; stemness; cancer; metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH-FACTOR RECEPTOR; TRANSCRIPTIONAL REPRESSORS ZEB1; SMAD-INTERACTING PROTEIN-1; GENE-EXPRESSION SIGNATURE; REGULATES E-CADHERIN; BREAST-CANCER; MIR-200; FAMILY; STEM-CELLS; MICRORNA EXPRESSION;

D O I：

10.1038/embor.2010.117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epithelial-to-mesenchymal transition (EMT) is a fundamental process in development and disease. Zinc-finger enhancer binding (ZEB) transcription factors (ZEB1 and ZEB2) are crucial EMT activators, whereas members of the miR-200 family induce epithelial differentiation. They are reciprocally linked in a feedback loop, each strictly controlling the expression of the other. Now data show that EMT not only confers cellular motility, but also induces stem-cell properties and prevents apoptosis and senescence. Thus the balanced expression of ZEB factors and miR-200 controls all these processes. We therefore propose that the ZEB/miR-200 feedback loop is the molecular motor of cellular plasticity in development and disease, and in particular is a driving force for cancer progression towards metastasis by controlling the state of cancer stem cells.

引用

页码：670 / 677

页数：8

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