Transferrin C2 variant does not confer a risk for Alzheimer's disease in Koreans

被引：13

作者：

Kim, KW

Jhoo, JH

Lee, JH

Lee, DY

Lee, KU

Youn, JY

Woo, JI ^{[1
]}

机构：

[1] Seoul Natl Univ, Neurosci Res Inst, Med Res Ctr, Seoul, South Korea

[2] Kyunggi Prov Hosp Elderly, Dept Neuropsychiat, Yongin, Kyunggi Do, South Korea

[3] Seoul Natl Univ Hosp, Clin Res Inst, Seoul 110744, South Korea

[4] Seoul Natl Univ, Res Inst Aging, Coll Med, Seoul, South Korea

[5] Seoul Natl Univ, Phys Culture Med Res Ctr, Coll Med, Seoul, South Korea

[6] Kangwon Natl Univ, Coll Med, Dept Neuropsychiat, Chunchon, Kangwon Do, South Korea

[7] Seoul Natl Mental Hosp, Dept Neuropsychiat, Seoul, South Korea

[8] Seoul Natl Univ, Coll Med, Dept Neuropsychiat, Seoul 110744, South Korea

来源：

NEUROSCIENCE LETTERS | 2001年 / 308卷 / 01期

关键词：

Alzheimer's disease; risk; transferrin; apolipoprotein E; age-at-onset; Koreans;

D O I：

10.1016/S0304-3940(01)01985-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We analyzed the transferrin (TF) and apolipoprotein E (APOE) genotypes of 164 probable Alzheimer's disease (AD) patients and 239 cognitively normal elderly controls in Koreans. We failed to detect a significant difference in genotypic frequencies and allelic frequencies of the TF polymorphism between the AD group and control group (P > 0.1 by Chi square test). The frequency of the TF C2 variant did not differ by the diagnosis when the APOE epsilon4-positive subjects and APOE epsilon4-negative subjects were analyzed separately (P > 0.1 by Chi square test). The TF C2 variant did not influence the age-at-onset of AD independently or synergistically with the occurrence of the APOE epsilon4 allele (P > 0.1 by ANOVA). The TF C2 variant did not confer a risk for AD in Koreans. (C) 2001 Published by Elsevier Science Ireland Ltd.

引用

页码：45 / 48

页数：4

共 19 条

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