Synaptic P2X receptors

被引:102
作者
Robertson, SJ
Ennion, SJ
Evans, RJ
Edwards, FA
机构
[1] Kings Coll London, Acad Dept Neurosurg, London SE5 9PJ, England
[2] Univ Leicester, Dept Cell Physiol & Pharmacol, Leicester LE1 9HN, Leics, England
[3] UCL, Dept Physiol, London WC1E 6BT, England
基金
英国惠康基金;
关键词
D O I
10.1016/S0959-4388(00)00222-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Over the past two years, ATP has clearly been shown to act as a co-transmitter with GABA, glycine and probably glutamate in the central nervous system. Our understanding of the ATP-gated P2X receptors is progressing rapidly, and the pharmacology, stoichiometry and subunit combinations of heteropolymeric P2X channels has been substantially elucidated.
引用
收藏
页码:378 / 386
页数:9
相关论文
共 79 条
  • [1] P2x2 receptor immunoreactivity in the dorsal vagal complex and area postrema of the rat
    Atkinson, L
    Batten, TFC
    Deuchars, J
    [J]. NEUROSCIENCE, 2000, 99 (04) : 683 - 696
  • [2] Bardoni R, 1997, J NEUROSCI, V17, P5297
  • [3] A protein kinase C site highly conserved in P2X subunits controls the desensitization kinetics of P2X2 ATP-gated channels
    Boué-Grabot, É
    Archambault, V
    Séguéla, P
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (14) : 10190 - 10195
  • [4] Desensitization of the P2X(2) receptor controlled by alternative splicing
    Brandle, U
    Spielmanns, P
    Osteroth, R
    Sim, J
    Surprenant, A
    Buell, G
    Ruppersberg, JP
    Plinkert, PK
    Zenner, HP
    Glowatzki, E
    [J]. FEBS LETTERS, 1997, 404 (2-3) : 294 - 298
  • [5] ACTIVATION OF SPECIFIC ATP RECEPTORS INDUCES A RAPID INCREASE IN INTRACELLULAR CALCIUM-IONS IN RAT HYPOTHALAMIC NEURONS
    CHEN, ZP
    LEVY, A
    LIGHTMAN, SL
    [J]. BRAIN RESEARCH, 1994, 641 (02) : 249 - 256
  • [6] Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice
    Cockayne, DA
    Hamilton, SG
    Zhu, QM
    Dunn, PM
    Zhong, Y
    Novakovic, S
    Malmberg, AB
    Cain, G
    Berson, A
    Kassotakis, L
    Hedley, L
    Lachnit, WG
    Burnstock, G
    McMahon, SB
    Ford, APDW
    [J]. NATURE, 2000, 407 (6807) : 1011 - 1015
  • [7] Collo G, 1996, J NEUROSCI, V16, P2495
  • [8] Cotrina ML, 2000, J NEUROSCI, V20, P2835
  • [9] Development of P2X receptor clusters on smooth muscle cells in relation to nerve varicosities in the rat urinary bladder
    Dutton, JL
    Hansen, MA
    Balcar, VJ
    Barden, JA
    Bennett, MR
    [J]. JOURNAL OF NEUROCYTOLOGY, 1999, 28 (01): : 3 - 16
  • [10] P2X1 receptor membrane redistribution and down-regulation visualized by using receptor-coupled green fluorescent protein chimeras
    Dutton, JL
    Poronnik, P
    Li, GH
    Holding, CA
    Worthington, RA
    Vandenberg, RJ
    Cook, DI
    Barden, JA
    Bennett, MR
    [J]. NEUROPHARMACOLOGY, 2000, 39 (11) : 2054 - 2066